The STROBE-Vet statement is a modification of the STROBE statement for use in reporting studies undertaken in animal populations. The original STROBE statement (www.STROBE-statement.org) was developed to provide guidance for the reporting of observational studies related to human health. The STROBE guidelines focus on cohort, case-control, and cross-sectional studies related to human medicine and public health, although many of the principles also apply to other observational study designs, such as hybrid designs or ecological studies. However, there are nuances of conducting and reporting studies in animal populations that are unique. Therefore, while the STROBE statement and the accompanying elaboration document provide an excellent resource for conducting, reporting, and reading observational studies, modifications to address specific issues in veterinary medicine will increase its applicability. Therefore, the STROBE-Vet statement was created as a modification of the STROBE statement to address issues in animal populations. The scope of the STROBE-Vet statement includes observational studies using samples/information of animal origin with outcomes related to animal health, production, welfare, or food safety. Thus, STROBE-Vet encompasses a broad range of veterinary research involving animals (including animal populations such as herds, farms, or flocks), products of animal origin (such as meat or milk), or samples from animals (such as blood or feces). Studies involving human health outcomes related to animal exposure were considered outside the scope of this initiative. For these studies, the original STROBE statement would be the appropriate guideline to use. From a study design perspective, the scope of STROBE-Vet includes both observational studies of hypotheses (hypothesis-driven or hypothesis generating) and population-based descriptive studies, such as those estimating the frequency and distribution of disease.